郭慧，女，1986年10月生，安徽阜阳人，博士，副教授，博士生导师，广东海洋大学优秀青年骨干教师，南海青年学者。2014年毕业于华南师范大学，主要研究方向为水产动物健康养殖生态和重要养殖生物对环境胁迫的响应机制。近5年主持各类项目10余项，其中主持国家级项目1项，省部级项目3项。获市厅级科技进步二等奖1项，指导本科生获得国家级大学生创新创业训练计划项目2项、全国大学生生命科学创新创业大赛一等奖1项、二等奖2项等；以第一或通讯作者发表学术论文二十余篇，其中SCI收录14篇；出版专著1部。

教育经历：

2011/09—2014/07，华南师范大学，生命科学学院，博士。

2008/09—2011/07，广东海洋大学，水产学院，硕士；

2004/09—2008/07，安徽科技学院，生物系，学士；

工作经历：

2018/10--至今 广东海洋大学，水产学院，副教授

2014/07—2018/10，广东海洋大学，水产学院，讲师

近5年主要科研项目：

1. 铜离子胁迫下凡纳滨对虾免疫相关MicroRNA的筛选鉴定与功能研究，国家自然科学基金， 2017.1-2019.12，20万，主持。

2. 铜离子胁迫下凡纳滨对虾血细胞的响应机理研究，广东省自然科学基金，2015.8-2018.8，10万，主持。

3. 广东海洋大学“南海青年学者”人才项目， 2018.01-2021.12，30万，主持。

4. 广东海洋大学“优秀青年骨干教师”人才项目，2016.1-2018.12，10万，主持。

主要代表性论文:

[1] Guo H, Liang Z, Zheng PH, et al. Effects of nonylphenol exposure on histological changes, apoptosis and time-course transcriptome in gills of white shrimp Litopenaeus vannamei, Science of the Total Environment,2021.

[2] Li L, Shen YC, Liang JR, Liu H, Chen TC, Guo H∗. Accumulation and Depuration of Cd and its Efect on the Expressions of Metallothionein and Apoptotic Genes in Litopenaeus vannamei, Bulletin of Environmental Contamination and Toxicology (2021) 106:501–506.

[3]Zhu Xufeng#, Guo H#, Li GL,et al. Effects of dietary hydrolyzable tannins on growth performance, antioxidant capacity, intestinal microflora and resistance against Vibrio parahaemolyticus of juvenile Pacific white shrimp, Litopenaeus vannamei (Boone, 1931), Aquaculture Reports, 2021, 19(100601)

[4] Guo H, Chen Tianci,LiangZhi,et al.iTRAQ and PRM-based comparative proteomic profiling in gills of white shrimp Litopenaeus vannamei under copper stress, Chemosphere,2020.

[5] Guo H, Deng MY, Liang JR, et al. Gill transcriptome alterations in Macrobrachium rosenbergii under copper exposure, Chemosphere, 2019, 233: 796-808.

[6] Guo H, Chen LL, Li GL, et al. Accumulation and depuration of nonylphenol and its effect on the expressions of vitellogenin and vitellogenin receptor in freshwater prawn Macrobrachium rosenbergii, Bulletin of Environmental Contamination and Toxicology, 2019, 103: 729-733

[7] Guo H, Lu ZC, Zhu XW, et al. Differential expression of microRNAs in hemocytes from white shrimp Litopenaeus vannamei under copper stress. Fish & Shellfish Immunology, 2018, 74:152-161.

[8] Wang W, YangSP, Wang CG, Shi LL, Guo H∗, Chan SM*. Gill transcriptomes reveal involvement of cytoskeleton remodeling and immune defense in ammonia stress response in the banana shrimp Fenneropenaeus merguiensis. Fish & Shellfish Immunology, 2017, 71: 319-328.

[9] Guo H, Li KX, Wang CG, et al. Effects of copper on hemocyte apoptosis, ROS production, and gene expression in white shrimp Litopenaeus vannamei. Biological Trace Element Research, 2017, 179: 318-36.

[10] Guo H, Xian JA, Wang AL. Analysis of digital gene expression profiling in hemocytes of white shrimp Litopenaeus vannamei under nitrite stress, Fish & Shellfish Immunology, 2016, 56:1-11.

[11] Guo H, Miao YT, Xian JA, et al. Expression profile of antioxidant enzymes in hemocytes from freshwater prawn Macrobrachium rosenbergii exposed to an Elevated level of copper. Bulletin of Environmental Contamination and Toxicology, 2015, 95:447-451.

[12] Guo H, Ye CX, Wang AL, et al. Transcriptome analysis of the Pacific white shrimp Litopenaeus vannamei exposed to nitrite by RNA-seq. Fish & Shellfish Immunology 2013, 35(6): 2008-2016.

[13] Guo H, Xian JA, Li B, et al. Gene expression of apoptosis-related genes, stress protein and antioxidant enzymes in haemocytes of white shrimp Litopenaeus vannamei under nitrite stress. Comparative Biochemistry and Physiology C 2013, 157: 366-371.

[14] Xian JA, Guo H, Li B, et al. Measurement of intracellular nitric oxide (NO) production in shrimp haemocytes by flow cytometry. Fish & Shellfish Immunology 2013, 35(6): 2032–2039.