董忠典（1987.11-）男，博士，副教授，硕士生导师。博士毕业于中国海洋大学，研究方向为水产动物繁育和水生生态毒理学。主讲本科生《水产动物育种学》、《分子生物学》《世界水产养殖》，研究生《水产种质保存理论与技术》、《水产动物繁殖生物学》等课程。主持国家自然科学基金等在内的7项科研基金，参与多项国家和省部及项目，目前已发表论文80余篇，其中第一/通讯作者50余篇，授权国家发明专利6项。

工作经历：

2022.01 - 至今    广东海洋大学 水产学院 水产养殖系 副教授

2016.07 - 2021.12，广东海洋大学 水产学院 水产养殖系 讲师

学习经历：

本科：2006.9-2010.6，山东农业大学，水产养殖专业；导师 王慧教授

硕士：2010.9-2013.6，山东农业大学，动物遗传育种与繁殖；导师 王慧教授

博士：2013.9-2016.6，中国海洋大学，水生生物学；导师 温海深教授、陈松林院士

主持项目：

1. 不同盐度下双酚A暴露对弓背青鳉的复合毒性效应，国家自然科学基金

2. 环境水平双酚AF对诸氏鲻虾虎鱼肝脏毒性效应及其机制研究，广东省自然科学基金面上项目

3. 舒氏猪齿鱼人工驯养及繁育技术攻关，广东省现代化海洋牧场适养品种核心技术攻关项目

4. BPA世代暴露对弓背青鳉毒性效应机制的研究，广东省特色青年项目

5. 转基因弓背青鳉的研制，广东海洋大学博士启动基金

6. 弓背青鳉环境内分泌干扰物检测转基因系开发，广东海洋大学水产优青

7. 双酚A及替代物对青鳉内分泌干扰效应及机制研究，广东海洋大学南海青年学者项目

主要参与项目：

1. 视蛋白基因在笛鲷属鱼类体色调控中的作用及机制研究，国家自然科学基金面上项目

2. 基于转录组和microRNA信息的牙鲆白化发生机制，国家基金面上项目

3. 17β-雌二醇对半滑舌鳎性腺蛋白质组调控机制的研究，山东省基金青年项目

4. 基于弓背青鳉高桥群体中无dmy雄性的性染色体转换机制研究，广东省自然科学基金面上项目

5. 不同盐度下孕激素对海洋青鳉的慢性毒性效应研究，广东省自然科学基金面上项目

近年部分代表论文：

1. Qu Z, Yuan B, Li R, Ba X, Zhuang Z, Yi X, Zhou J, Min Q, Dong Z, Zhao N,Zhang B. (2025). Integrated omics analysis reveals the effect of feeding scarcity on the lipid metabolism and apoptosis in Nibea coibor. Aquaculture. 596.

2. Zhang N, Yi X, He H, Liu Y, Zhang B, Dong Z, Zhao N. (2025). Microalgae Oocystis borgei promotes the recovery of florfenicol-induced disorders in Oryzias melastigma microbiota. Aquaculture. 598.

3. Zhang N, Ren J, Hong T, Dong Z, Li F, Zhang Y, Huang X, Li C, Hu Z. (2025). Identification of stable reference genes for qPCR analysis of gene expression in Oocystis borgei under various abiotic conditions. Algal Research-Biomass Biofuels and Bioproducts. 86.

4. Dong Z, Wang J, Chen G, Guo Y, Zhao N, Wang Z, Zhang B. (2024). A high-quality chromosome-level genome assembly of the Chinese medaka Oryzias sinensis. Scientific Data. 11(1).

5. Li H, Gao J, Liu Y, Ding Y, Guo Y, Wang Z, Dong Z, Zhang N, Sinha A K. (2024). Toxic Effects of Bisphenol AF Exposure on the Reproduction and Liver of Female Marine Medaka (Oryzias melastigma). Animals. 14(2).

6. Chen Z, Zhang G, Xie M, Zheng Z, Chen Y, Zhang N, Guo Y, Wang Z, Dong Z. (2024). Toxic effects of environmental concentration Bisphenol AF exposure on the survival, growth and reproduction of adult male Oryzias curvinotus. Comparative Biochemistry and Physiology C-Toxicology & Pharmacology. 280.

7. Chen Z, Li X, Gao J, Liu Y, Zhang N, Guo Y, Wang Z, Dong Z. (2024). Reproductive toxic effects of chronic exposure to bisphenol A and its analogues in marine medaka (Oryzias melastigma). Aquatic Toxicology. 271.

8. Chen Z, Li X, Gao J, Liu Y, Zhang N, Guo Y, Wang Z, Dong Z. (2024). Effects of salinity on behavior and reproductive toxicity of BPA in adult marine medaka. Chemosphere. 357: 142103-142103.

9. Chen Z, Zhou T, Chen X, Huan Z, Huang J, Lu S, Zeng M, Guo Y, Wang Z, Dong Z. (2024). Toxic effects of chronic exposure to BPAF and perturbation of gut microbiota homeostasis in marine medaka (Oryzias melastigma). The Science of the total environment. 957: 177745-177745.

10. Zhou S, Lin H, Liu Z, Lian X, Pan C-G, Dong Z, Lin Z, Li C, Hou L, Liang Y-Q. (2024). The impact of co-exposure to polystyrene microplastics and norethindrone on gill histology, antioxidant capacity, reproductive system, and gut microbiota in zebrafish (Danio rerio). Aquatic Toxicology. 273.

11. Mai S, Liang Y-Q, Zhou S, Lin H, Dong Z, Pan C-G, Kong Q, Wang S, Wang S, Lin Z, Hou L. (2024). The long-term effects of norgestrel on the reproductive and thyroid systems in adult zebrafish at environmentally relevant concentrations. Aquatic toxicology (Amsterdam, Netherlands). 276: 107105-107105.

12. Li M, Zhang N, Huang Y, Pan C-G, Dong Z, Lin Z, Li C, Jiang Y-X, Liang Y-Q. (2024). The effects of 17α-methyltestosterone on gonadal histology and gene expression along hypothalamic-pituitary-gonadal axis, germ cells, sex determination, and hypothalamus-pituitary-thyroid axis in zebrafish (Danio rerio). Environmental Toxicology. 39(3): 1494-1504.

13. Huang Y, Liu X, Wang H-Y, Chen J-Y, Zhang X, Li Y, Lu Y, Dong Z, Liu K, Wang Z, Wang Q, Fan G, Zou J, Liu S, Shao C. (2024). Single-cell transcriptome landscape of zebrafish liver reveals hepatocytes and immune cell interactions in understanding nonalcoholic fatty liver disease. Fish & Shellfish Immunology. 146.

14. Chen L, Liang Q, Lai Z, Cui H, Xu Z, Chen Z, Dong Z, Wang Z, Guo Y. (2024). Systematic selection of suitable reference genes for quantitative real-time PCR normalization studies of gene expression in Lutjanus erythropterus. Scientific Reports. 14(1).

15. Dong, Z., X. Li, Y. Chen, N. Zhang, Z. Wang, Y.-Q. Liang and Y. Guo (2023). "Short-term exposure to norethisterone affected swimming behavior and antioxidant enzyme activity of medaka larvae and led to masculinization in the adult population." Chemosphere 310: 136844.

16. Liang Y-Q, Zhong L, Jiang M, Lu M, Li C, Dong Z, Lin Z. (2023) . "Physiological and transcriptional effects in the male western mosquitofish (Gambusia affinis) following exposure to dexamethasone. " Ecotoxicology and Environmental Safety. 254: 114722.

17. Li X, He X, Lin X, Li W, Gao J, Zhang N, Guo Y, Wang Z, Zhao N, Zhang B, Dong Z. (2023). "Effects of bisphenols on lipid metabolism and neuro-cardiovascular toxicity in marine medaka larvae. " Aquatic Toxicology. 259: 106551.

18. Huang Z, Gao J, Chen Y, Huan Z, Liu Y, Zhou T, Dong Z. (2023). "Toxic effects of bisphenol AF on the embryonic development of marine medaka (Oryzias melastigma)." Environmental Toxicology. 38: 1445-1454.

19. Zhao N, Wang Q, Deng Q, Dong Z, Zhang B. (2023). "Heterogeneity of sex-biased miRNAs profiling of Cynoglossus semilaevis between exosome and sperm. "Aquaculture. 563.

20. Zhao N, Guo H-B, Jia L, Dong Z, Zhang B. (2022). "The genome assembly of flathead grey mullet Mugil cephalus." Frontiers in Marine Science. 9.

21. Zhao N, Jia L, Chen L, Lin J, Dong Z, Zhang B. (2022). "Integrative sperm DNA methylation and miRomics analysis highlights interaction of two epigenetic patterns of pseudomale inheritance in teleost." Frontiers in Marine Science. 9.

22. Yang Y, Dong Z, Chen X, Wang Z, Zhang D, Liang L,Mu W. (2022). "Molecular characterization and expression analysis of hypoxia-inducible factor-1 alpha, factor-2 alpha, and factor-3 alpha and physiological response to hypoxia exposure in Amur minnow (Phoxinus lagowskii)." Aquaculture International. 30(2): 607-632.

23. Wang Z, Dong Z, Yang Y, Wang J, Yang T, Chen X, Liang L,Mu W. (2022). "Histology, physiology, and glucose and lipid metabolism of Lateolabrax maculatus under low temperature stress." Journal of Thermal Biology. 104.

24. Qi Q, Dong Z, Zhang N, Shao C,Xu W. (2022). "A patched1 gene homologue participates in female differentiation of Cynoglossus semilaevis." Gene expression patterns : GEP. 45: 119265-119265.

25. Pan X, Li W, Warren A, Dong Z. (2022). "Tetrahymena pyriformis infection in the tiger barb, Puntius tetrazona: Parasite characterization and pathology of infected fish." Aquaculture. 549.

26. Liang Q, Afriyie G, Chen Z, Xu Z, Dong Z, Guo Y,Wang Z. (2022) . "Analysis of opsin gene family of Crimson snapper (Lutjanus erythropterus). " Gene. 807.

27. Dong, Z., Y. Chen, X. Li, N. Zhang, Y. Guo, Y.-Q. Liang and Z. Wang (2022). "Norethindrone alters growth, sex differentiation and gene expression in marine medaka (Oryzias melastigma)." Environmental Toxicology 37(5): 1211-1221.

28. Dong, Z., Y. Chen, H. Li, Z. Huan, X. Li, N. Zhang, Y. Guo, C. Shao and Z. Wang (2022). "Liver comparative transcriptome analysis reveals the mechanism of the Hainan medaka, Oryzias curvinotus, to adapt to salinity." Journal of the World Aquaculture Society.

29. Li, X., Y. Liu, Y. Chen, X. Song, X. Chen, N. Zhang, H. Li, Y. Guo, Z. Wang and Dong Z. (2022). "Long-term exposure to bisphenol A and its analogues alters the behavior of marine medaka (Oryzias melastigma) and causes hepatic injury." Science of the Total Environment 841.

30. Chen, Y., X. Chen, X. Li, Y. Liu, Y. Guo, Z. Wang and Z. Dong (2022). "Effects of bisphenol AF on growth, behavior, histology and gene expression in marine medaka (Oryzias melastigma)." Chemosphere 308(Pt 3): 136424-136424.

31. Dong, Z., X. Li, Z. Yao, C. Wang, Y. Guo, Q. Wang, C. Shao and Z. Wang (2021). "Oryzias curvinotus in Sanya Does Not Contain the Male Sex-Determining Gene dmy." Animals 11(5).

32. Dong-Neng Jiang, Z.-Y. K., Kong-Song Yang, Yuan-Qing Huang, Umar Farouk Mustapha, Xiang-Zhao Guo, De-Feng Zheng, Zhong-Dian Dong, Hong-Juan Shi (2021). "Polymorphism in a sex-linked DNA marker located on LG23 in Hainan strain of Nile tilapia (Oreochromis niloticus)." Journal of the World Aquaculture Society: 1-19.

33. Li, X., X. Lin, Y. Chen, Z. Wang, Y. Guo, G. Afriyie, N. Zhang and Z. Dong (2021). "Norethisterone exposure alters the transcriptome of Marine Medaka (Oryzias melastigma) larvae." Chemistry and Ecology 37(9-10): 767-779.

34. Liang, Y.-Q., C.-G. Pan, L. Xie, J. Huo, J. Yang, T. Lan, Z. Dong and M. Duan (2021). "Histological and transcriptional effects of androstenedione in adult zebrafish (Danio rerio)." Environmental Toxicology 36(4): 598-606.

35. Dong, Z., X. Li, S. Huang, N. Zhang, Y. Guo and Z. Wang (2020). "Vitellogenins and choriogenins are biomarkers for monitoring Oryzias curvinotus juveniles exposed to 17 beta - estradiol." Comparative Biochemistry and Physiology C-Toxicology & Pharmacology 236.

36. Liang, Y.-Q., Z. Jing, C.-G. Pan, Z. Lin, Z. Zhen, L. Hou and Z. Dong (2020). "The progestin norethindrone alters growth, reproductive histology and gene expression in zebrafish (Danio rerio)." Chemosphere 242.

37. Afriyie, G., Z. Wang, Z. Dong, C. Ayisi Larbi, B. Asiedu and Y. Guo (2020). "Complete mitochondrial genome and assembled DNA barcoding analysis of Lutjanus fulgens (Valenciennes, 1830) and its comparison with other Lutjanus species." Ecology and Evolution 10(15): 7971-7980.

38. Dong, Z., N. Zhang, Y. Liu, W. Xu, Z. Cui, C. Shao and S. Chen (2019). "Expression analysis and characterization of zglp1 in the Chinese tongue sole (Cynoglossus semilaevis)." Gene 683: 72-79.

39. Dong, Z., P. Chen, N. Zhang, S. Huang, H. Zhang, S. Wang, X. Li, Y. Guo and Z. J. G. R. Wang (2019). "Evaluation of reference genes for quantitative real-time PCR analysis of gene expression in Hainan medaka (Oryzias curvinotus)." 14: 94-99.

40. Wang, Q., Q. Liu, W. Ma, R. Wang, S. Li, Z. Dong and C. Shao (2022). "A Potential Role of the Translation Elongation Factor eef1a1 in Gonadal High-Temperature Perception in Chinese Tongue Sole (Cynoglossus semilaevis)." Animals 12(13).

41. Zhang, N., Z. Dong, W. Xu, Z. Cui, Q. Wang and S. Chen (2020). "Molecular characterization and expression pattern of inhibin alpha and beta b in Chinese tongue sole (Cynoglossus semilaevis)." Gene Expression Patterns 38.

42. Zhang, N., H. Zhang, Z. Dong and W. Wang (2022). "Molecular Identification of Nocardia seriolae and Comparative Analysis of Spleen Transcriptomes of Hybrid Snakehead (Channa maculata Female x Channa argus Male) With Nocardiosis Disease." Frontiers in Immunology 13.

43. 董忠典, 宦章, 黎学友, 陈月碧, 张宁, 郭昱嵩, 王中铎, 梁燕秋. 广东海洋大学学报 (2022). "炔诺酮短期暴露对海洋青鳉仔鱼的毒性效应." 42(6): 9.

44. 董忠典, 黎学友, 黄承勤, 张海瑞, 黄顺楷, 张宁, 郭昱嵩, 王中铎 (2021). "湖栖鳍虾虎鱼性腺转录组比较分析 水产学报." 45(03): 365-380.

45. 董忠典, 黎学友, 廖健, 张宁, 郭昱嵩, 王中铎 (2020). "雌、雄弓背青鳉(Oryzias curvinotus)肝脏转录组比较分析 海洋与湖沼." 51(05): 1203-1213.

46. 董忠典, 张宁, 崔忠凯, 徐文腾, 陈松林 (2019). "半滑舌鳎gata5基因的克隆及表达分析 广东海洋大学学报."  39(03): 6-14.

47. 周天洋, 陈月碧, 高佳豪, 王中铎, 郭昱嵩,董忠典. (2024).双酚AF对海水青鳉仔鱼心血管和神经系统毒性效应. 中国环境科学. 44(05): 2724-2732.

48. 黄健旋, 刘悦, 黎学友, 王中铎, 郭昱嵩,董忠典. 2024,盐度对弓背青鳉行为及肠道菌群的影响. 农业与技术. 44(13): 114-120.

49. 黄泽胤, 陈月碧, 黎学友, 张宁, 郭昱嵩, 王中铎, 董忠典 (2022). "盐度胁迫对弓背青鳉水通道蛋白基因转录的影响生物技术." 32(04): 415-420.

50. 黎学友, 谢明花, 黄承勤, 汪淳, 王中铎, 郭昱嵩, 董忠典 (2021). "湖栖鳍虾虎鱼皮肤和眼睛转录组比较 水产学报." 45(08): 1317-1326.

51. 廖嘉仪, 黎学友, 王淑茹, 陈普顺, 宋欣霖, 谢明花, 王中铎, 郭昱嵩, 张宁, 董忠典 (2021). "弓背青鳉zglp1基因的克隆和表达分析 基因组学与应用生物学." 40(04): 1481-1487.

52. 黄皓, 林晓雨, 张宁, 董忠典 (2021). "重金属铜、铅、锌对尾草履虫的联合毒性. 基因组学与应用生物学." 40(Z3): 3073-3078.

53. 梁燕秋, 司徒艳结, 董忠典, 许文强, 梁杏仪, 景占鑫 (2020). "炔诺酮对斑马鱼肠道免疫调节因子的干扰效应 广东海洋大学学报." 40(03): 1-6.

54. 黄顺楷, 郭昱嵩, 汪淳, 张海瑞, 王淑如, 董忠典 (2019). "弓背青鳉3种雌激素受体基因的克隆及其表达分析 广东海洋大学学报." 39(02): 8-19.

55. 梁燕秋, 董忠典, 黄国勇, 田斐, 李进, 应光国 (2019). "黄体酮对成年斑马鱼下丘脑-垂体-性腺轴相关基因转录表达的干扰效应 生态科学." 38(02): 1-8.

专利

1. 山奈酚在制备改善鱼类产卵功能损伤的产品中的应用，授权公告号CN 118948835 B（第一完成人）

2. 一种快速鉴定弓背青鳉遗传性别的引物及其应用，授权公告号CN 107385095（第一完成人）

3. 一种半滑舌鳎性染色体连锁的DNA片段及其应用，授权公告号CN 105331724 B（第二完成人）

4. 一种基于基因组编辑的海水鲆鲽鱼类种质构建方法及应用，授权公告号CN105671084 B（第9完成人）

5. 一种可悬挂西施舌养殖分苗装置，授权公告号：CN 214508811 U（第四完成人）

6. 一种西施舌增殖放流专用网框，授权公告号：CN 2015302375 U（第四完成人）

联系方式：zddong@gdou.edu.cn