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罗大极*

职称/职位: 二级教授/博士生导师,学院院长

研究方向: 鱼类遗传育种

实验室(办公)位置: 兴海楼410-2

联系电话: 18986281862

Email: luodaji@gdou.edu.cn 或luodaji@ihb.ac.cn

学习经历

1999/09至2003/06,武汉大学生命科学学院,生物学基地班,学士

2003/09至2008/06,武汉大学生命科学学院,遗传学(导师:朱作言院士),博士(硕博连读)

主要工作经历与任职情况

2008/07至2019/05,武汉大学,遗传学系,讲师(2008)、副教授(2011)、硕士生导师(2012)、博士生导师(2018)

2019/06至今,中国科学院水生生物研究所,研究组组长/研究员/博士生导师

2025/09至今,广东海洋大学水产学院院长,教授/博士生导师

主要社会兼职

中国生物化学与分子生物学会农业专业分会常务委员

中国水产学会水产生物技术与遗传育种专业委员会委员

中国动物学会比较内分泌学专业委员会委员

中国动物学会斑马鱼分会委员

Scientific Data,Zoological Research,《水生生物学报》和《农业生物技术学报》等国内外学术期刊编委。

主要奖励和个人荣誉

2024年获国家杰出青年科学基金资助

2020年获中国科学院百人计划择优资助

2020年获湖北省杰出青年基金项目资助

2019年获湖北五一劳动奖章

2019年获国家优秀青年科学基金资助

2019年获中国科学院水生生物研究所“青年科技奖”

2018年获第四届全国高校青年教师教学竞赛一等奖

2017年“湖北青年教学能手”荣誉称号

2016年获第四届湖北省高校青年教师教学竞赛一等奖

2016年获武汉大学“十佳教师”

2015年获武汉大学十大杰出青年(教职工)

2011年获香港中文大学“内地杰出学人计划”资助

主要教学情况

本科生:《遗传学》、《细胞生物学》、《基因组学》、《鱼类遗传育种学》等

研究生:《鱼类生物学与生物技术》等

主要研究领域及兴趣

1.鱼类性反转与遗传育种

2.鱼类RNA生物学与生物技术

3.水产分子育种技术与种质创制

主要项目情况

1.国家自然科学基金杰青项目,鱼类性反转机制,2025/01-2029/12,主持

2.国家自然科学基金优青项目,鱼类遗传育种学,2020/01-2022/12,主持

3.中国科学院百人计划(择优),鱼类RNA生物学,2020/01-2024/05,主持

4.湖北省重点研发项目,黄鳝优良种质创制关键技术研究,2023/12-2025/12,主持

5.湖北省杰青项目,黄鳝性别控制基础理论与种质创制研究,2021/01-2023/12,主持

代表性论文(著作)

1. Meng K, Hu M, Chen Y, Lin X, Jiang C, Song J, Bai Y, Zhao Y, Liu F, Luo D.(2025) Natural sex reversal imparts permanent compositional changes to the swamp eel gonadal microbiome. Microbiome. DOI : 10.1186/s40168-025-02187-7.

2. Lin X, Zhao Y, Bai Y, Meng K, Chen Y, Hu M, Liu F, Luo D. (2025) Integrating gonadal RNA-seq and small RNA-seq to analyze mRNA and miRNA changes in medaka sex differentiation.Scientific Data. 12(1):778.

3. Han Y, Sun K, Yu S, Qin Y, Zhang Z, Luo J, Hu H, Dai L, Cui M, Jiang C, Liu F, Huang Y, Gao P, Chen X, Xin T, Ren X, Wu X, Song J, Wang Q, Tang Z, Chen J, Zhang H, Zhang X, Liu M, Luo D. (2024) A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO Journal. 43(10):1990-2014. 

4. Zhao Y, Duan M, Lin X, Li W, Liu H, Meng K, Liu F, Hu W, Luo D. (2024) Molecular underpinnings underlying behaviors changes in the brain of juvenile common carp (Cyrinus carpio) in response to warming. Journal of Advanced Research. 63:43-56. 

5. Zhao Y, Chen Z, Hu M, Liu H, Zhao H, Huang Y, Jiang M, Li S, Li G, Zhu C, Hu W, Luo D. (2024) Integrating Iso-seq and RNA-seq data for the reannotation of the greater amberjack genome. Scientific Data.11(1):675.

6. Chen Y, Lin X, Dai J, Bai Y, Liu F, Luo D. (2024) Deletion of ddx4 Ovary-Specific Transcript Causes Dysfunction of Meiosis and Derepress of DNA Transposons in Zebrafish Ovaries.Biology (Basel). 13(12):1055.

7. Chen H, Luo D. (2023) Application of haematology parameters for health management in fish farms. Reviews in Aquaculture. 15: 704-737.  (Cover story)

8. Meng K, Lin X, Chen Y, Hu M, Hu W, Luo D. (2023) Integrated analysis of the digestive tract bacterial community on individual growth in sibling generation of Swamp Eels (Monopterus albus). Aquaculture. 566 (1): 739228. 

9. Liu F, Lin X, Meng K, Chen Y, Liu H, Zhao Y, Luo D. (2023) Identification of potential indicators for testis quality in swamp eels (Monopterus albus) through metabolomics analysis. Water Biology and Security. 2(2): 100204.

10. Meng K, Lin X, Liu H, Chen H, Liu F, Xu Z, Sun Y, Luo D. (2022) Gonadal bacterial community composition is associated with sex-specific differences in Swamp eels (Monopterus albus). Frontiers in Immunology. 13: 938326.

11. Zhao Y, Chen K, Liu F, Jiang M, Chen Z, Chen H, Song Y, Tao B, Cui X, Li Y, Zhu Z, Chen J, Hu W, Luo D. (2022) Dynamic gene expression and alternative splicing events demonstrate co-regulation of testicular differentiation and maturation by the brain and gonad in Common Carp. Frontiers in Endocrinology. 12: 820463.

12. Liu F, Qin Y, Huang Y, Gao P, Li J, Yu S, Jia D, Chen X, Lv Y, Tu J, Sun K, Han Y, Reilly J, Shu X, Lu Q, Tang Z, Xu C, Luo D, Liu M. (2022) Rod genesis driven by mafba in an nrl knockout zebrafish model with altered photoreceptor composition and progressive retinal degeneration. PLOS Genetics. 18: e1009841. 

13. Li Y, Chen Z, Liu H, Li Q, Lin X, Ji S, Li R, Li S, Fan W, Zhao H, Zhu Z, Hu W, Zhou Y, Luo D. (2021) ASER: Animal Sex Reversal Database. Genomics, Proteomics & Bioinformatics.19:873-881. (Cover story) 

14. Chen H, Liu H, Li R, Lin X, Luo H, Ji S, Hu W, Luo D. (2021) Blood cell identification and hematological analysis during natural sex reversal in rice field eel (Monopterus albus). Aquaculture. 538 (11): 736543.

15. Yu S#, Jiang T#, Jia D, Han Y, Liu F, Huang Y, Qu Z, Zhao Y, Tu J, Lv Y, Li J, Hu X, Lu Z, Han S, Qin Y, Liu X, Xie S, Wang QK, Tang Z, Luo D, Liu M. (2019) BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis. Blood. 133:805-815. (Cover story) 

16. Zhou B, Li X, Luo D, Lim DH, Zhou Y, Fu XD. (2019) GRID-seq for comprehensive analysis of global RNA-Chromatin interactions. Nature Protocols. 14:2036-2068. 

17. Xiao R, Chen JY, Liang Z,Luo D, Chen G, Lu Z, Chen Y, Zhou B, Li H, Du X, Yang Y, San KM, Wei X, Liu W, Lecuyer E, Graveley BR, Yeo G, Burge CB, Zhang QM, Zhou Y, Fu XD.(2019) Pervasive Chromatin-RNA binding protein interactions enable RNA-based regulation of transcription. Cell. 178:107-121.

18. Luo D, Feng K, Zhu Z, Hu W.(2019)Genrating gene knockout Oryzias Latipes and Rice Field eel using TALENs method. Methods in Molecular Biology. 1874:489-506.

19. Qiu C, Cheng B, Zhang Y, Huang R, Liao L, Li Y,Luo D, Hu W, Wang Y.(2014) Efficient knockout of transplanted green fluorescent protein gene in Medaka using TALENs.Marine Biotechnology.16:674-83. (Cover story)

20. Liu Y,Luo D, Lei Y, Hu W, Zhao H, Cheng CH.(2014) A high effective TALEN-mediated approach for targeted gene disruption inXenopus tropicalisand zebrafish.Methods. 69:58-66.

21. Luo D, Hu W, Chen S, Zhu Z.(2011) Critical developmental stages for the efficiency of somatic cell nuclear transfer in zebrafish.International Journal of Biological Sciences.7: 476-486.

22. Luo D, Hu W, Chen S, Xiao Y, Sun Y, Zhu Z.(2009) Identification of differentially expressed genes between cloned and zygote-developing zebrafish embryos at the dome stage using suppression subtractive hybridization.Biology of Reproduction. 80: 674-684.